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KMID : 0043320090320040489
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Archives of Pharmacal Research
2009 Volume.32 No. 4 p.489 ~ p.494
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Anti-acne Activities of Pulsaquinone, Hydropulsaquinone, and Structurally Related 1, 4-Quinone Derivatives
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Moon Surk-Sik
Sultan Md Zakir
Cho Soon-Chang
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Abstract
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Quinone type compound, pulsaquinone 1, isolated from the aqueous ethanol extract of the roots of Pulsatilla koreana exhibited antimicrobial activities against an anaerobic non-sporeforming gram-positive bacillus, Propionibacterium acnes, which is related with the pathogenesis of the inflamed lesions in a common skin disease, acne vulgaris. Compound 1 was unstable on standing and thus converted to more stable compound 2, namely hydropulsaquinone by hydrogenation, whose activity was comparable to mother compound 1 (MIC for 1 and 2 against P. acnes: 2.0 and 4.0 μg/mL, respectively). Other structurally-related quinone derivatives (3-13) were also tested for structure-activity relationship against anaerobic and aerobic bacteria, and fungi. The antimicrobial activity was fairly good when the quinone moiety was fused with a nonpolar 6- or 7-membered ring on the right side whether or not conjugated (1,4-naphtoquinone derivatives 3-5), while simple quinone compounds 6-9 showed poor activity. It seems that the methoxy groups at the left side of the quinone function deliver no considerable antimicrobial effect.
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KEYWORD
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Pulsatilla koreana, Pulsaquinone, Hydropulsaquinone, Anti-acne, Propionibacterium acnes
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